BBC: Genetic Parkinson’s disease brain cells made in lab

By Michelle RobertsHealth reporter, BBC News

 

Scientists in the US have successfully made human brain cells in the lab that are an exact replica of genetically caused Parkinson’s disease.

The breakthrough means they can now see exactly how mutations in the parkin gene cause the disease in an estimated one in 10 patients with Parkinson’s.

And it offers a realistic model to test new treatments on – a hurdle that has blighted research efforts until now.

The team told Nature Communications their work was a “game-changer”.

Lab-grown

“This is the first time that human dopamine neurons have ever been generated from Parkinson’s disease patients with parkin mutations,” said Dr Jian Feng who led the investigations.

“Before this, we didn’t even think about being able to study the disease in human neurons.

“The brain is so fully integrated. It’s impossible to obtain live human neurons to study.”

Studying human neurons is critical in Parkinson’s disease since animal models that lack the parkin gene do not develop the condition, rendering them useless for this research purpose.

To make the human neurons the scientists used a technique already successfully tested by others which can turn donated skin cells into brain tissue.

They used skin samples from four volunteers – two healthy people and two with Parkinson’s disease caused by a parkin gene mutation.

This allowed them to observe the parkin gene at work.

 

Read more here. 

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s